MORU’s research programme aims to improve the health and well-being of people living in low-resource settings across the tropical world through high quality science and its translation. We will conduct clinical and laboratory research on diseases that disproportionately affect disadvantaged communities. Through discovery research we will identify and understand these health threats, and then innovate affordable and deployable solutions to counter them. We address health challenges along the entire patient pathway, from the village health worker to the intensive care unit. We will address major challenges, with the aim of benefitting hundreds of millions of people. We will focus on infectious diseases and maternal and child health, and the emerging health threats of antimicrobial resistance and climate change. We are committed to ethical research practices and community engagement to ensure our work is relevant. We will improve the techniques to assess and optimise new and existing antimicrobial treatments, and then conduct high-quality clinical trials to assess them. We will strengthen stakeholder partnerships and collaborations to ensure our research agenda is equitably set, and our research is translated into impact. We will develop local research leaders and build research capacity to improve health outcomes and contribute to a more equitable world.