The Wellcome Centre for Integrative Parasitology (WCIP) has evolved through Trust support since 1987 into a world-leading and cutting-edge research hub. We now propose a further transformation to take us and the field forward through the integration of disciplines, locations and scales, to tackle disease problems in disease endemic regions (DER). Our 2014 renewal broadened our portfolio of pathogens and technologies and grew the Centre at every level. Our PI complement increased from 9 to 15, including numerous Fellowship and Investigator Award holders (6F/5M). World-leading recruits from Harvard, Oxford and Edinburgh together with young emerging (female) PIs radically extended the Centre’s activities. We have new programmes on immunology, helminths and their population structures, single cell bioinformatics, and clinical pathology of parasitic diseases. Technologically, we have expanded with dedicated technologists in both imaging and metabolomics, while internationally, fruitful engagement with Malawi has embedded Centre members in key areas such as paediatric malaria, epidemiology and enhanced training opportunities. Our strategic growth reflects the evolution of our vision from the intense, largely laboratory-based investigation of parasite biology into the integrated pursuit of WCIP-generated knowledge-based therapies positioned by informed interactions with Global Health stakeholders in Glasgow and selected partners across Europe and particularly DER.