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At the UK Dementia Research Institute (UK DRI), we are aiming to produce large, reliable datasets related to neurodegenerative disease which, as well as being a central pillar of UK DRI research, can also be reanalysed by scientists at other institutes. Acquisition of the human whole-genome DNA methylation microarrays would directly synergise with this strategic focus of the UK DRI on big data ‘omics techniques and provide a resource which could be shared with other members of Cardiff University and other UKDRI centres.The Human Genome-wide DNA Methylation Microarrays will allow us to understand the methylation profiles of Alzheimer's disease and healthy control individuals. These DNA methylation profiles will allow us to perform epigenome-wide association studies (EWAS) and calculate/estimate epigenetic clocks of individuals. The results from these will be combined with other Genetic and Genomic data from the same individuals.
(WA Ref:125847)Relates to the following project/programme financed by EU Community Funds: The project is funded by Sêr Cymru "Rising Star" fellowship awarded to Dr Dobril Ivanov by the European Regional Development Fund (ERDF) through the Welsh Government (CU-147).
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